Lab Phone:(773) 702-1067
B.A. Department of Chemistry, Carleton College, Northfield, MN (1999)
Ph.D. Chemistry, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA (2005)
Chromatin is the physiologic form of the genome. Rather than serving as mere packaging, chromatin structure acts as a key regulator of underlying DNA function. Local chromatin structure may be stable for decades, yet is sufficiently dynamic to respond to signaling pathways, potentiating transcriptional program changes in cell signaling and development. Indeed cellular identity and changes thereof are intimately connected to chromatin states-- keeping a neuron a neuron and not a liver cell. How is cellular identity established, maintained and transmitted to the next generation? What are the mechanisms of disease states that occur as a consequence of disregulation of these processes?
The unifying theme of my laboratory is the elucidation of molecular mechanisms governing chromatin structure and epigenetic information flow using the toolkits of functional genomics, biochemistry, chemical and structural biology. In particular, we are interested in how posttranslational modifications and noncoding RNA can control chromatin structure. Projects ideally will transition from discovery biochemistry to detailed molecular and structural investigation.